Article
Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
Journal of cellular physiology - 1 Sept 2018
Myers Valerie D, Tomar Dhanendra, Madesh Muniswamy, Wang JuFang, Song Jianliang, Zhang Xue-Qian, Gupta Manish K, Tahrir Farzaneh G, Gordon Jennifer, McClung Joseph M, Kontos Christopher D, Khalili Kamel, Cheung Joseph Y, Feldman Arthur M
Abstract excerpt
Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid protein that is found predominantly in the heart, skeletal muscle, and many cancers. Deletions and truncations in BAG3 that result in haplo-insufficiency have been associated with the development of dilated cardiomyopathy. To study the cellular and molecular events attributable to BAG3 haplo-insufficiency we generated a mouse in which one allele of BAG3 was...
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