Article
Regulation of antigen-receptor gene assembly in hagfish.
EMBO reports - 1 Feb 2010
Kishishita Natsuko, Matsuno Tatsuya, Takahashi Yoshimasa, Takaba Hiroyuki, Nishizumi Hirofumi, Nagawa Fumikiyo
Abstract excerpt
Variable lymphocyte receptors (VLRs) are antigen receptors in the jawless vertebrates lamprey and hagfish. VLR genes are classified into VLRA and VLRB, and lymphocytes expressing VLRA are T-cell-like, whereas those expressing VLRB are B-cell-like in the sea lamprey. Diverse VLR genes are assembled somatically in lymphocytes; however, how the assembly is regulated is still largely unknown. Here, we analyse VLR...
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