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Article

Dual nature of the adaptive immune system in lampreys.

Nature - 11 Jun 2009

Guo Peng, Hirano Masayuki, Herrin Brantley R, Li Jianxu, Yu Cuiling, Sadlonova Andrea, Cooper Max D

Abstract excerpt

Jawless vertebrates use variable lymphocyte receptors (VLR) comprised of leucine-rich-repeat (LRR) segments as counterparts of the immunoglobulin-based receptors that jawed vertebrates use for antigen recognition. Highly diverse VLR genes are somatically assembled by the insertion of variable LRR sequences into incomplete germline VLRA and VLRB genes. Here we show that in sea lampreys (Petromyzon marinus) VLRA...

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Identifiers

PMID: 19474790
DOI: 10.1038/nature08068
PMCID: PMC2714547

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MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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