Article
Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates.
Proceedings of the National Academy of Sciences of the United States of America - 14 Dec 2021
Das Sabyasachi, Rast Jonathan P, Li Jianxu, Kadota Mitsutaka, Donald John A, Kuraku Shigehiro, Hirano Masayuki, Cooper Max D
Abstract excerpt
Three types of variable lymphocyte receptor (VLR) genes, VLRA, VLRB, and VLRC, encode antigen recognition receptors in the extant jawless vertebrates, lampreys and hagfish. The somatically diversified repertoires of these VLRs are generated by serial stepwise copying of leucine-rich repeat (LRR) sequences into an incomplete germline VLR gene. Lymphocytes that express VLRA or VLRC are T cell-like, while...
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