Article
Selection of the lamprey VLRC antigen receptor repertoire.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2014
Holland Stephen J, Gao Mingming, Hirano Masayuki, Iyer Lakshminarayan M, Luo Ming, Schorpp Michael, Cooper Max D, Aravind L, Mariuzza Roy A, Boehm Thomas
Abstract excerpt
The alternative adaptive immune system of jawless vertebrates is based on different isotypes of variable lymphocyte receptors (VLRs) that are composed of leucine-rich repeats (LRRs) and expressed by distinct B- and T-like lymphocyte lineages. VLRB is expressed by B-like cells, whereas VLRA and VLRC are expressed by two T-like lineages that develop in the thymoid, a thymus-like structure in lamprey larvae. In each...
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