Article
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice.
Nature immunology - 1 Feb 2007
Nagawa Fumikiyo, Kishishita Natsuko, Shimizu Kazumichi, Hirose Satoshi, Miyoshi Masato, Nezu Junnya, Nishimura Toshinobu, Nishizumi Hirofumi, Takahashi Yoshimasa, Hashimoto Shu-ichi, Takeuchi Masaki, Miyajima Atsushi, Takemori Toshitada, Otsuka Anthony J, Sakano Hitoshi
Abstract excerpt
Jawless vertebrates have acquired immunity but do not have immunoglobulin-type antigen receptors. Variable lymphocyte receptors (VLRs) have been identified in lamprey that consist of multiple leucine-rich repeat (LRR) modules. An active VLR gene is generated by the assembly of a series of variable gene segments, including many that encode LRRs. Stepwise assembly of the gene segments seems to occur by replacement...
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