Article
Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase.
Nature immunology - 1 Jun 2007
Rogozin Igor B, Iyer Lakshminarayan M, Liang Lizhi, Glazko Galina V, Liston Victoria G, Pavlov Youri I, Aravind L, Pancer Zeev
Abstract excerpt
The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-rich repeat modules that serve as sequence templates for the hypervariable VLR repertoires. The...
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