Article
Light-dependent behavioral phenotypes in PER3-deficient mice.
Journal of biological rhythms - 1 Feb 2010
van der Veen Daan R, Archer Simon N
Abstract excerpt
A functional knockout of Period3 in mice (mPer3(-/-)) results in a mildly altered circadian phenotype, and mPer3 shows a redundant role within the circadian clock. In this study, the authors reevaluated the Per3(-/ -) behavioral phenotype on a C57Bl/6J background and report altered responses to light. In constant light, free-running activity period was shorter than that of wild-type, whereas in constant darkness,...
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