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Article

Mop3 is an essential component of the master circadian pacemaker in mammals.

Cell - 22 Dec 2000

Bunger M K, Wilsbacher L D, Moran S M, Clendenin C, Radcliffe L A, Hogenesch J B, Simon M C, Takahashi J S, Bradfield C A

Abstract excerpt

Circadian oscillations in mammalian physiology and behavior are regulated by an endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known as BMAL1) in mice results in immediate and complete loss of circadian rhythmicity in constant darkness. Additionally, locomotor activity in light-dark (LD) cycles is impaired and activity levels are reduced in Mop3-/- mice. Analysis of Period gene...

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Source

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Identifiers

PMID: 11163178
DOI: 10.1016/s0092-8674(00)00205-1
PMCID: PMC3779439

Genes

BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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