Article
Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light.
Journal of biological rhythms - 1 Jun 2006
Abraham Diya, Dallmann Robert, Steinlechner Stephan, Albrecht Urs, Eichele Gregor, Oster Henrik
Abstract excerpt
In mammals, circadian rhythms in behavior and physiology are controlled by a central pacemaker, the SCN, and subordinated clocks throughout the body. On the molecular level, these clocks are based on transcriptional/translational feedback loops involving a set of clock genes that regulate their own transcription. Among the components driving the mammalian circadian clock are the Period 1 and 2 (Per1 and Per2) and...
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