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Article

Allelic variant at -79 (C>T) in CDKN1B (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels.

Endocrine-related cancer - 1 Jun 2010

Landa Iñigo, Montero-Conde Cristina, Malanga Donatella, De Gisi Silvia, Pita Guillermo, Leandro-García Luis-Javier, Inglada-Pérez Lucía, Letón Rocío, De Marco Carmela, Rodríguez-Antona Cristina, Viglietto Giuseppe, Robledo Mercedes

Abstract excerpt

The aim of this study is to assess if common genetic variants located in the CDKN1B locus, coding for the cell cycle inhibitor p27(Kip1), are involved in thyroid cancer susceptibility. Based on the literature and functional predictions, we selected three polymorphisms within the CDKN1B gene (rs2066827 (T326G, V109G), rs34330 (-79C>T) and rs36228499 (-838C>A)) to perform the first case-control study in thyroid...

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PMID: 20075119
DOI: 10.1677/ERC-09-0016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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