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CCND1 Splice Variant as A Novel Diagnostic and Predictive Biomarker for Thyroid Cancer

13 Nov 2018

Abstract excerpt

Cyclin D1 protein is aberrantly overexpressed in thyroid cancers, but mutations of the CCND1 gene are rare in these tumors. We investigated the CCND1 rs9344 (G870A) polymorphism and the expression profiles of wild-type CCND1a and shortened oncogenic isoform CCND1b at the mRNA and protein levels in 286 thyroid tumors. Genotype AA of rs9344 was associated with high expression of CCND1b mRNA and was more frequently...

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PMID: 30428594
DOI: 10.3390/cancers10110437

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