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Article

Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma.

Cancer research - 1 Oct 2007

Ruiz-Llorente Sergio, Montero-Conde Cristina, Milne Roger L, Moya Christian M, Cebrián Arancha, Letón Rocío, Cascón Alberto, Mercadillo Fátima, Landa Iñigo, Borrego Salud, Pérez de Nanclares Guiomar, Alvarez-Escolá Cristina, Díaz-Pérez José Angel, Carracedo Angel, Urioste Miguel, González-Neira Anna, Benítez Javier, Santisteban Pilar, Dopazo Joaquín, Ponder Bruce A, Robledo Mercedes

Abstract excerpt

To date, few association studies have been done to better understand the genetic basis for the development of sporadic medullary thyroid carcinoma (sMTC). To identify additional low-penetrance genes, we have done a two-stage case-control study in two European populations using high-throughput genotyping. We selected 417 single nucleotide polymorphisms (SNP) belonging to 69 genes either related to RET signaling...

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Share to Carcinoma, Medullary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p15

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Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-ret

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Source

Identifiers

PMID: 17909067
DOI: 10.1158/0008-5472.CAN-07-1638

Genes

AURKA
BCL2
CDK6
COMT
HRAS
RET
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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