Article
Fine mapping of T-cell immunoglobulin mucin domain gene 1 failed to detect a significant association with multiple sclerosis.
Tissue antigens - 1 Mar 2010
Grabmer C, Nachbauer W, Schanda K, Feurle P, Loacker K, Scholz E, Schennach H, Berger T, Reindl M, Gassner C
Abstract excerpt
The T-cell immunoglobulin mucin (TIM) gene family encodes receptors on T-cells that regulate Th1- and Th2-cell-mediated immunity. Recently published data implied differential expression of human TIM molecules by mononuclear cells in cerebrospinal fluid of patients with multiple sclerosis (MS) and might therefore be involved in different phases of the pathogenesis of MS. The purpose of this study was to...
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