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Article

Molecular variations in Th1-specific cell surface gene Tim-3.

Experimental & molecular medicine - 30 Jun 2004

Chae Soo-Cheon, Song Ju-Hee, Pounsambath Pann, Yuan Hai-Ying, Lee Jae-Hoon, Kim Jeong-Joong, Lee Yong-Chul, Chung Hun-Taeg

Abstract excerpt

The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3) is selectively expressed on the surface of differentiated Th1 cells. Tim-3 might have an important role in the induction of autoimmune diseases by regulating macrophage activation and interacts with Tim-3 ligand to regulate Th1...

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Source

Identifiers

PMID: 15272240
DOI: 10.1038/emm.2004.37

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Molecular variations in Th1-specific cell surface gene Tim-3.PMID 15272240Read ↗

The association of TIM-3 gene polymorphism with atopic disease in Korean population.Semantic proximity Read ↗

The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis.Semantic proximity Read ↗

Association between +4259 T>G and -574 G>T Polymorphisms of TIM-3 with Asthma in an Iranian Population.Semantic proximity Read ↗

Association between Gene Polymorphisms of T Cell Immunoglobulin Domain and Mucin Domain-3 and Risk of Asthma: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

[Linkage disequilibrium analysis of -1516, -574 and 4259 single nucleotide polymorphisms in TIM-3 gene].Semantic proximity Read ↗

Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma.Semantic proximity Read ↗

The +4259A>C polymorphism of TIM-3 but not -1637C>T polymorphism of TIM-1 is associated with Multiple sclerosis in Isfahan population.Semantic proximity Read ↗

Lack of association of TIM3 polymorphisms and allergic phenotypes.Semantic proximity Read ↗

T cell immunoglobulin- and mucin-domain-containing molecule 3 gene polymorphisms and susceptibility to pancreatic cancer.Semantic proximity Read ↗

[The relationship between the haplotype of T cells immunoglobulin mucin-3 gene and allergic asthma in the Han population from Hubei province of China].Semantic proximity Read ↗

Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population.Semantic proximity Read ↗

TIM-3 genetic variants and risk of Behçet disease in the Iranian population.Semantic proximity Read ↗

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