Article
Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population.
Mutagenesis - 1 Jul 2011
Li Wen-Xian, Chen Gui-Mei, Yuan Hui, Yao Ying-Shui, Li Ruo-Jie, Pan Hai-Feng, Li Xiang-Pei, Xu Jian-Hua, Tao Jin-Hui, Ye Dong-Qing
Abstract excerpt
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune diseases, which affects multiple organ systems such as kidney. The imbalance of T-helper 1 (Th1)/Th2 cells is critical in the pathogenesis of SLE. The T-cell immunoglobulin mucin (TIM) proteins comprise a family of cell surface molecules expressed on T cells that regulate Th1- and Th2-cell-mediated immunity. Recent work has found increased...
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