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Article

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.

Journal of neurochemistry - 1 Mar 2010

Hsu Cindy H, Chan Diane, Greggio Elisa, Saha Shamol, Guillily Maria D, Ferree Andrew, Raghavan Kesav, Shen Grace C, Segal Lilach, Ryu Hoon, Cookson Mark R, Wolozin Benjamin

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are prevalent causes of late-onset Parkinson's disease. Here, we show that LRRK2 binds to MAPK kinases (MKK) 3, 6, and 7, and that LRRK2 is able to phosphorylate MKK3, 6 and 7. Over-expression of LRRK2 and MKK6 increased the steady state levels of...

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Identifiers

PMID: 20067578
DOI: 10.1111/j.1471-4159.2010.06568.x
PMCID: PMC2856721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20067578-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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