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Investigating Convergent Actions of Genes Linked to Familial Parkinson’s Disease

1 Jan 2008

Abstract excerpt

BACKGROUND: Mutations in LRRK2 are among the most frequent genetic changes identified in Parkinson's disease (PD), but how LRRK2 contributes to the pathophysiology of PD is not known. OBJECTIVES: To investigate how expressing wild-type or G2019S LRRK2 modifies cellular responses to rotenone, a mitochondrial toxin. METHODS: We investigated the vulnerability to mitochondrial toxins in Caenorhabditis elegans...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 18322385
DOI: 10.1159/000113697

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