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Article

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.

Journal of neurochemistry - 1 Dec 2015

Civiero Laura, Cirnaru Maria Daniela, Beilina Alexandra, Rodella Umberto, Russo Isabella, Belluzzi Elisa, Lobbestael Evy, Reyniers Lauran, Hondhamuni Geshanthi, Lewis Patrick A, Van den Haute Chris, Baekelandt Veerle, Bandopadhyay Rina, Bubacco Luigi, Piccoli Giovanni, Cookson Mark R, Taymans Jean-Marc, Greggio Elisa

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a causative gene for Parkinson's disease, but the physiological function and the mechanism(s) by which the cellular activity of LRRK2 is regulated are poorly understood. Here, we identified p21-activated kinase 6 (PAK6) as a novel interactor of the GTPase/ROC domain of LRRK2. p21-activated kinases are serine-threonine kinases that serve as targets for the small GTP binding...

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Identifiers

PMID: 26375402
DOI: 10.1111/jnc.13369
PMCID: PMC4715492

Genes

PAK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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