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Article

Regulation of physiologic actions of LRRK2: focus on autophagy.

Neuro-degenerative diseases - 1 Jan 2012

Ferree Andrew, Guillily Maria, Li Hu, Smith Katelyn, Takashima Aki, Squillace Rachel, Weigele Manfred, Collins James J, Wolozin Benjamin

Abstract excerpt

BACKGROUND: Mutations in LRRK2 are associated with familial and sporadic Parkinson's disease (PD). Subjects with PD caused by LRRK2 mutations show pleiotropic pathology that can involve inclusions containing α-synuclein, tau or neither protein. The mechanisms by which mutations in LRRK2 lead to this pleiotropic pathology remain unknown. OBJECTIVES: To investigate mechanisms by which LRRK2 might cause PD. METHODS:...

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Identifiers

PMID: 22204929
DOI: 10.1159/000332599
PMCID: PMC3363354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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