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Article

Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.

PloS one - 1 Jan 2011

Yuan Yiyuan, Cao Pengxiu, Smith Mark A, Kramp Kristopher, Huang Ying, Hisamoto Naoki, Matsumoto Kunihiro, Hatzoglou Maria, Jin Hui, Feng Zhaoyang

Abstract excerpt

Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease (PD), manifested as age-dependent dopaminergic neurodegeneration, but the underlying molecular mechanisms remain unclear. Multiple roles of LRRK2 may contribute to dopaminergic neurodegeneration. Endoplasmic reticulum (ER) stress has also been linked to PD pathogenesis, but its interactive mechanism with PD...

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Identifiers

PMID: 21857923
DOI: 10.1371/journal.pone.0022354
PMCID: PMC3153934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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