Article
The continuing search for predisposing colorectal cancer variants.
Cancer genomics & proteomics - 1 Jan 2000
Picelli Simone, Von Holst Susanna, Wessendorf Petra
Abstract excerpt
High-penetrance mutations in a small group of genes have been identified as the causal agent of colorectal cancer (CRC) in high-risk families. Our understanding of the sporadic cases is, however, much more limited and only in the past two years have multicentric genome-wide association studies (GWAS) started to unravel the complex genetic architecture behind this common forms. To date, ten loci have been...
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