Article
Genetic architecture of colorectal cancer.
Gut - 1 Oct 2015
Peters Ulrike, Bien Stephanie, Zubair Niha
Abstract excerpt
Colorectal cancer (CRC) is a complex disease that develops as a consequence of both genetic and environmental risk factors. A small proportion (3-5%) of cases arise from hereditary syndromes predisposing to early onset CRC as a result of mutations in over a dozen well defined genes. In contrast, CRC is predominantly a late onset 'sporadic' disease, developing in individuals with no obvious hereditary syndrome. In...
Topics
- Colorectal Neoplasms
- DNA, Neoplasm
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mutation
- Risk Factors