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Article

Refined QTLs of osteoporosis-related traits by linkage analysis with genome-wide SNPs: Framingham SHARe.

Bone - 1 Apr 2010

Karasik David, Dupuis Josée, Cho Kelly, Cupples L Adrienne, Zhou Yanhua, Kiel Douglas P, Demissie Serkalem

Abstract excerpt

Genome-wide association studies (GWAS) using high-density array of single-nucleotide polymorphisms (SNPs) offer an unbiased strategy to identify new candidate genes for osteoporosis. We used a subset of autosomal SNPs from the Affymetrix 500K+50K SNP GeneChip marker set to examine genetic linkage with multiple highly heritable osteoporosis-related traits, including BMD of the hip and spine, heel ultrasound...

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Bone and Bones
Bone Density
Genetic Linkage
Osteoporosis
Patient Selection

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Regression Analysis

Ultrasonography

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PMID: 20064633
DOI: 10.1016/j.bone.2010.01.001
PMCID: PMC2842472

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