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Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study.

Bone - 1 Mar 2007

Demissie S, Dupuis J, Cupples L A, Beck T J, Kiel D P, Karasik D

Abstract excerpt

INTRODUCTION: Femoral geometry contributes to bone strength and predicts hip fracture risk. The purpose of this study was to evaluate heritability (h(2)) of geometric indices of the proximal hip and to perform whole-genome linkage analyses of these traits, adjusted for body size. METHODS: DXA scans of the proximal femur from 1473 members of 323 pedigrees (age range 31-96 years) from the population-based...

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Absorptiometry, Photon
Aged, 80 and over
Body Mass Index
Femur
Genetic Linkage

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PMID: 17079199
DOI: 10.1016/j.bone.2006.09.020
PMCID: PMC1952180

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