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Article

Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.

Journal of autoimmunity - 1 Aug 2010

Behrens Marshall, Trejo Theodore, Luthra Harvinder, Griffiths Marie, David Chella S, Taneja Veena

Abstract excerpt

HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by which DR4 is associated with sex-bias of arthritis. Here we show that differential antigen-specific...

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Identifiers

PMID: 20061120
DOI: 10.1016/j.jaut.2009.12.007
PMCID: PMC2878859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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