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Article

Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats.

Arthritis and rheumatism - 1 Aug 2012

Taurog Joel D, Rival Claudia, van Duivenvoorde Leonie M, Satumtira Nimman, Dorris Martha L, Sun Margaret, Shelton John M, Richardson James A, Hamra F Kent, Hammer Robert E, Tung Kenneth S K

Abstract excerpt

OBJECTIVE: Male rats transgenic for HLA-B27 and human β(2) -microglobulin (hβ(2) m) spontaneously develop epididymoorchitis (EO) preceding the development of spondylarthritis (SpA). In the specific B27/hβ(2) m-transgenic rat cross-strain (21-3 × 382-2)F(1) , only the males develop SpA, and neither sex develops gut inflammation. This study was undertaken to determine whether EO and SpA in male (21-3 × 382-2)F(1)...

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Identifiers

PMID: 22488218
DOI: 10.1002/art.34480
PMCID: PMC3396784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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