Article
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2013
Holoshitz Joseph, Liu Ying, Fu Jiaqi, Joseph Jeena, Ling Song, Colletta Alessandro, Sharma Prannda, Begun Dana, Goldstein Steven, Taichman Russell
Abstract excerpt
Particular alleles of HLA contribute to disease susceptibility and severity in many autoimmune conditions, but the mechanisms underlying these associations are often unknown. In this study, we demonstrate that the shared epitope (SE), an HLA-DRB1-coded sequence motif that is the single most significant genetic risk factor for erosive rheumatoid arthritis, acts as a signal transduction ligand that potently...
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