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Article

BuChE K variant is decreased in Alzheimer's disease not in fronto-temporal dementia.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Mar 2010

Bizzarro Alessandra, Guglielmi V, Lomastro R, Valenza A, Lauria A, Marra C, Silveri M C, Tiziano F D, Brahe C, Masullo C

Abstract excerpt

Alzheimer's disease (AD) is characterized by a significant reduction in AcetylCholinesterase and an increase in ButyrylCholinesterase (BuChE) activity. The existence of polymorphic regions on the BuChE gene has been previously described; the most frequently found polymorphism is the so-called K variant, which leads to a 30% decreased enzymatic activity. Different studies reported a positive association between K...

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Source

Identifiers

PMID: 20058037
DOI: 10.1007/s00702-009-0358-y

Genes

APOE

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