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Article

Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients.

Neuroscience letters - 19 Sept 2008

Tasker Andrea, Ballard Clive G, Joachim Catharine, Warden Donald R, Okello Edward J, Perry Robert H, Khan Nadeem, Smith A David, Lehmann Donald J, Perry Elaine K

Abstract excerpt

There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from three centres: Newcastle, Oxford and London. Mean BuChE...

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Identifiers

PMID: 18640242
DOI: 10.1016/j.neulet.2008.07.023

Genes

BCHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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