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Article

Association between butyrylcholinesterase and cerebrospinal fluid biomarkers in Alzheimer's disease patients.

Neuroscience letters - 22 Feb 2017

Gabriel António José, Almeida Maria Rosário, Ribeiro Maria Helena, Durães João, Tábuas-Pereira Miguel, Pinheiro Ana Cristina, Pascoal Rui, Santana Isabel, Baldeiras Inês

Abstract excerpt

The deficit of cholinergic activity is one of the main findings in Alzheimer's disease (AD), and is related to the synthesis of acetylcholine, and the hydrolysing enzymes, acetylcholinesterase and butyrylcholinesterase (BuChE). Together with the Apolipoprotein E-ε4 allele (ApoE-ε4), the BuChE-K variant has been proposed to increase AD risk in certain populations. In addition, this polymorphism has been associated...

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Identifiers

PMID: 28108398
DOI: 10.1016/j.neulet.2017.01.036

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