Article
The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patients.
Dementia and geriatric cognitive disorders - 1 Jan 2005
Ballard Clive, Morris Christopher, Kalaria Rajesh, McKeith Ian, Perry Robert, Perry Elaine
Abstract excerpt
Accumulating evidence suggests that butyrylcholinesterase (BuChE) plays an important role in the progression of cognitive deficits and Alzheimer-type pathology in dementia patients. We examined the relationship between the K variant of BuChE and the severity of deposits of amyloid (Abeta(1-42)) and phosphorylated tau in the temporal cortex (BA36) of 30 prospectively studied autopsy-diagnosed dementia (Alzheimer's...
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