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Article

Substitution of basic amino acids within endonuclease V enhances nontarget DNA binding.

The Journal of biological chemistry - 25 Mar 1991

Nickell C, Anderson W F, Lloyd R S

Abstract excerpt

Several DNA-interactive proteins, including the DNA repair enzyme T4 endonuclease V, have been shown to locate their target recognition sites utilizing an electrostatically mediated facilitated diffusion mechanism. Previous work indicates that a decrease in the affinity of endonuclease V for nontarget DNA results in an increased nontarget dissociation rate. This study was designed to investigate the effect of an...

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PMID: 2005104

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