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Article

Biological significance of facilitated diffusion in protein-DNA interactions. Applications to T4 endonuclease V-initiated DNA repair.

The Journal of biological chemistry - 25 Feb 1990

Dowd D R, Lloyd R S

Abstract excerpt

Facilitated diffusion along nontarget DNA is employed by numerous DNA-interactive proteins to locate specific targets. Until now, the biological significance of DNA scanning has remained elusive. T4 endonuclease V is a DNA repair enzyme which scans nontarget DNA and processively incises DNA at the site of pyrimidine dimers which are produced by exposure to ultraviolet (UV) light. In this study we tested the...

Topics

Biological Transport
DNA Repair
Deoxyribonuclease (Pyrimidine Dimer)
Diffusion
Endodeoxyribonucleases
Escherichia coli
Kinetics
Mutation
Osmolar Concentration
Plasmids
T-Phages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ultraviolet Rays

Viral Proteins

Source

Identifiers

PMID: 2406255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2406255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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