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Article

Exploring the DNA mimicry of the Ocr protein of phage T7.

Nucleic acids research - 1 Sept 2012

Roberts Gareth A, Stephanou Augoustinos S, Kanwar Nisha, Dawson Angela, Cooper Laurie P, Chen Kai, Nutley Margaret, Cooper Alan, Blakely Garry W, Dryden David T F

Abstract excerpt

DNA mimic proteins have evolved to control DNA-binding proteins by competing with the target DNA for binding to the protein. The Ocr protein of bacteriophage T7 is the most studied DNA mimic and functions to block the DNA-binding groove of Type I DNA restriction/modification enzymes. This binding prevents the enzyme from cleaving invading phage DNA. Each 116 amino acid monomer of the Ocr dimer has an unusual...

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Identifiers

PMID: 22684506
DOI: 10.1093/nar/gks516
PMCID: PMC3439906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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