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Article

Identifying amino acid residues that contribute to the cellular-DNA binding site on retroviral integrase.

Virology - 20 Jun 2009

Nowak Matthew G, Sudol Malgorzata, Lee Noelle E, Konsavage Wesley M, Katzman Michael

Abstract excerpt

Although retroviral integrase specifically trims the ends of viral DNA and inserts these ends into any sequence in cellular DNA, little information is available to explain how integrase distinguishes between its two DNA substrates. We recently described novel integrase mutants that were improved for specific nicking of viral DNA but impaired at joining these ends into nonviral DNA. An acidic or bulky substitution...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19447461
DOI: 10.1016/j.virol.2009.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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