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Article

Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups.

Journal of Korean medical science - 1 Aug 2013

Shin Joong-Gon, Cheong Hyun Sub, Kim Jason Yongha, Kim Lyoung Hyo, Han Chang Soo, Kim Ji On, Kim Hae Deun, Kim Young Hoon, Chung Myeon Woo, Han Soon Young, Shin Hyoung Doo

Abstract excerpt

Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution of DPYD, we directly sequenced 288 subjects from five ethnic groups (96 Koreans, 48 Japanese, 48 Han Chinese, 48 African Americans, and 48 European Americans). As a result, 56...

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Identifiers

PMID: 23960437
DOI: 10.3346/jkms.2013.28.8.1129
PMCID: PMC3744698

Genes

DPYD

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Screening of dihydropyrimidine dehydrogenase genetic variants by direct sequencing in different ethnic groups.PMID 23960437Read ↗

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Opportunistic analysis of clinically actionable DPYD gene variants in a germline testing cohort in India.Semantic proximity Read ↗

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