Article
Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Apr 2010
Juhasz Gabriella, Downey Darragh, Hinvest Neal, Thomas Emma, Chase Diana, Toth Zoltan G, Lloyd-Williams Kathryn, Mekli Krisztina, Platt Hazel, Payton Antony, Bagdy Gyorgy, Elliott Rebecca, Deakin J F William, Anderson Ian M
Abstract excerpt
Decision making, choosing the best option from the possible outcomes, is impaired in many psychiatric conditions including affective disorders. We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. A population cohort (N=1035) completed a paper-and-pencil gambling task, filled out...
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