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Article

Curriculum Vitae of WEE2 Kinase in Homeostasis and Diseases: A Systematic Review.

Cells - 24 Jun 2026

Wang Ran, Yu Jing, Liu Yan-Jun, Zhao Guo-Shu, Li Xiang, Jiang Yi-Fang, Li Chang-Hong, Yang Guan-Jun, Chen Jiong

Abstract excerpt

WEE2, an oocyte-specific kinase of the WEE family, is a core regulator of oocyte meiosis. It maintains germinal vesicle (GV) arrest and prevents premature meiotic resumption by phosphorylating cyclin-dependent kinase 1 (CDK1), thereby inhibiting maturation-promoting factor (MPF) activity. WEE2 also regulates exit from metaphase II (MII), ensuring orderly meiotic progression. Consequently, the functional integrity...

Topics

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Cell Cycle Proteins
CDK1 gene
Homeostasis
Meiosis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

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Open in PubMed Open full text

Identifiers

PMID: 42439624
DOI: 10.3390/cells15131147
PMCID: PMC13359739

Genes

WEE2
CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Related research

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Curriculum Vitae of WEE2 Kinase in Homeostasis and Diseases: A Systematic Review.PMID 42439624Read ↗

Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic ProgressionSemantic proximity Read ↗

Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in miceSemantic proximity Read ↗

Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis†Semantic proximity Read ↗

The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle.Semantic proximity Read ↗

Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.Semantic proximity Read ↗

An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans.Semantic proximity Read ↗

Ste20‐like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytesSemantic proximity Read ↗

Novel mutations in WEE2: Expanding the spectrum of mutations responsible for human fertilization failureSemantic proximity Read ↗

Novel compound heterozygous mutations in WEE2 causes female infertility and fertilization failureSemantic proximity Read ↗

Novel WEE2 compound heterozygous mutations identified in patients with fertilization failure or poor fertilization.Semantic proximity Read ↗

Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†Semantic proximity Read ↗

WEE2 Is an Oocyte-Specific Meiosis Inhibitor in Rhesus Macaque Monkeys1Semantic proximity Read ↗

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