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Article

Determinants of Swe1p degradation in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Oct 2002

McMillan John N, Theesfeld Chandra L, Harrison Jacob C, Bardes Elaine S G, Lew Daniel J

Abstract excerpt

Swe1p, the sole Wee1-family kinase in Saccharomyces cerevisiae, is synthesized during late G1 and is then degraded as cells proceed through the cell cycle. However, Swe1p degradation is halted by the morphogenesis checkpoint, which responds to insults that perturb bud formation. The Swe1p stabilization promotes cell cycle arrest through Swe1p-mediated inhibitory phosphorylation of Cdc28p until the cells can...

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Identifiers

PMID: 12388757
DOI: 10.1091/mbc.e02-05-0283
PMCID: PMC129966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Determinants of Swe1p degradation in Saccharomyces cerevisiae.PMID 12388757Read ↗

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Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.Semantic proximity Read ↗

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.Semantic proximity Read ↗

Clb2 and the APC/C(Cdh1) regulate Swe1 stability.Semantic proximity Read ↗

Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle.Semantic proximity Read ↗

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.Semantic proximity Read ↗

Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.Semantic proximity Read ↗

Mathematical model of the morphogenesis checkpoint in budding yeast.Semantic proximity Read ↗

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