Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdk1-dependent regulation of the mitotic inhibitor Wee1.

Cell - 12 Aug 2005

Harvey Stacy L, Charlet Alyson, Haas Wilhelm, Gygi Steven P, Kellogg Douglas R

Abstract excerpt

The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis. We report here that Swe1, the budding-yeast homolog of Wee1, is directly regulated by Cdk1. Phosphorylation of Swe1 by Cdk1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2 Protein Kinase
Share to CDC28 Protein Kinase, S cerevisiae
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitosis

Share to Phosphorylation

Share to Protein-Tyrosine Kinases

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 16096060
DOI: 10.1016/j.cell.2005.05.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdk1-dependent regulation of the mitotic inhibitor Wee1.PMID 16096060Read ↗

Cdk1 and SUMO regulate Swe1 stability.Semantic proximity Read ↗

Cdc5 interacts with the Wee1 kinase in budding yeast.Semantic proximity Read ↗

Wee Kinases, Big Impact: Wee and Myt Kinases as Critical Regulators of Meiotic ProgressionSemantic proximity Read ↗

Nucleocytoplasmic trafficking of G2/M regulators in yeast.Semantic proximity Read ↗

The Fcp1-Wee1-Cdk1 axis affects spindle assembly checkpoint robustness and sensitivity to antimicrotubule cancer drugsSemantic proximity Read ↗

A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast.Semantic proximity Read ↗

Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.Semantic proximity Read ↗

Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.Semantic proximity Read ↗

Curriculum Vitae of WEE2 Kinase in Homeostasis and Diseases: A Systematic Review.Semantic proximity Read ↗

Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethalitySemantic proximity Read ↗

Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.Semantic proximity Read ↗

Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.