Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

14 Dec 2017

Abstract excerpt

Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that function in pathways critical to cancer cell growth. Tankyrase-mediated PARylation marks protein targets for proteasomal degradation. Here, we generate human knockout cell lines to examine cell function and interrogate the proteome. We show that either tankyrase 1 or 2 is sufficient to maintain telomere length, but both are required to resolve telomere...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29263426
DOI: 10.1038/s41467-017-02363-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradationPMID 29263426Read ↗

Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.Semantic proximity Read ↗

Tankyrase 2 Poly(ADP-Ribose) Polymerase Domain-Deleted Mice Exhibit Growth Defects but Have Normal Telomere Length and CappingSemantic proximity Read ↗

Role for the Related Poly(ADP-Ribose) Polymerases Tankyrase 1 and 2 at Human TelomeresSemantic proximity Read ↗

Tankyrase promotes telomere elongation in human cellsSemantic proximity Read ↗

Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.Semantic proximity Read ↗

Tankyrase, a positive regulator of telomere elongation, is over expressed in human breast cancerSemantic proximity Read ↗

Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin LigasesSemantic proximity Read ↗

Identification of a Tankyrase-binding Motif Shared by IRAP, TAB182, and Human TRF1 but Not Mouse TRF1Semantic proximity Read ↗

Targeting the PARylation-Dependent Ubiquitination Signaling Pathway for Cancer TherapiesSemantic proximity Read ↗

Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient MiceSemantic proximity Read ↗

Aneuploidy triggers a TFEB-mediated lysosomal stress responseSemantic proximity Read ↗

The telomeric PARP, tankyrases, as targets for cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.