Article
A genome-wide perspective of genetic variation in human metabolism.
Nature genetics - 1 Feb 2010
Illig Thomas, Gieger Christian, Zhai Guangju, Römisch-Margl Werner, Wang-Sattler Rui, Prehn Cornelia, Altmaier Elisabeth, Kastenmüller Gabi, Kato Bernet S, Mewes Hans-Werner, Meitinger Thomas, de Angelis Martin Hrabé, Kronenberg Florian, Soranzo Nicole, Wichmann H-Erich, Spector Tim D, Adamski Jerzy, Suhre Karsten
Abstract excerpt
Serum metabolite concentrations provide a direct readout of biological processes in the human body, and they are associated with disorders such as cardiovascular and metabolic diseases. We present a genome-wide association study (GWAS) of 163 metabolic traits measured in human blood from 1,809 participants from the KORA population, with replication in 422 participants of the TwinsUK cohort. For eight out of nine...
Topics
- Delta-5 Fatty Acid Desaturase
- Genetic Loci
- Genetic Variation
- Genome, Human
- Genome-Wide Association Study
- Humans
- Metabolome
- Polymorphism, Single Nucleotide
- Reproducibility of Results