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Article

Genetic determinants influencing human serum metabolome among African Americans.

PLoS genetics - 1 Mar 2014

Yu Bing, Zheng Yan, Alexander Danny, Morrison Alanna C, Coresh Josef, Boerwinkle Eric

Abstract excerpt

Phenotypes proximal to gene action generally reflect larger genetic effect sizes than those that are distant. The human metabolome, a result of multiple cellular and biological processes, are functional intermediate phenotypes proximal to gene action. Here, we present a genome-wide association study of 308 untargeted metabolite levels among African Americans from the Atherosclerosis Risk in Communities (ARIC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24625756
DOI: 10.1371/journal.pgen.1004212
PMCID: PMC3952826

Genes

NAT8
TREH
ACE
ACY3
ADH4
CPS1
GATM
KLKB1
SIAE
THEM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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