Article
The influence of rare variants in circulating metabolic biomarkers.
PLoS genetics - 1 Mar 2020
Riveros-Mckay Fernando, Oliver-Williams Clare, Karthikeyan Savita, Walter Klaudia, Kundu Kousik, Ouwehand Willem H, Roberts David, Di Angelantonio Emanuele, Soranzo Nicole, Danesh John, Wheeler Eleanor, Zeggini Eleftheria, Butterworth Adam S, Barroso Inês
Abstract excerpt
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy participants. We leveraged the information from multiple metabolite measurements on the same participants to improve discovery in rare variant association analyses for gene-based and gene-set...
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