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Article

Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development.

Development (Cambridge, England) - 1 Dec 2003

Macatee Timothy L, Hammond Benjamin P, Arenkiel Benjamin R, Francis Lily, Frank Deborah U, Moon Anne M

Abstract excerpt

Fibroblast growth factor 8 (Fgf8) is expressed in many domains of the developing embryo. Globally decreased FGF8 signaling during murine embryogenesis results in a hypomorphic phenotype with a constellation of heart, outflow tract, great vessel and pharyngeal gland defects that phenocopies human deletion 22q11 syndromes, such as DiGeorge. We postulate that these Fgf8 hypomorphic phenotypes result from disruption...

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Source

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Identifiers

PMID: 14623825
DOI: 10.1242/dev.00850
PMCID: PMC1876660

Genes

FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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