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Article

Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice

5 Apr 2006

Abstract excerpt

OBJECTIVE: Myocardial progenitor cells expressing Fgf10 give rise to the outflow tract and right ventricle of the mammalian heart. In order to define the role of fibroblast growth factor (FGF) signaling in this process we investigated whether Fgf10 or the major Fgf10 receptor Fgfr2-IIIb are required for normal heart development. METHODS: The cardiac phenotype of Fgf10 and Fgfr2-IIIb mutant mice was analysed by...

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PMID: 16687131
DOI: 10.1016/j.cardiores.2006.03.021

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