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Article

An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart

3 Oct 2008

Abstract excerpt

In order to understand how secreted signals regulate complex morphogenetic events, it is crucial to identify their cellular targets. By conditional inactivation of Fgfr1 and Fgfr2 and overexpression of the FGF antagonist sprouty 2 in different cell types, we have dissected the role of FGF signaling during heart outflow tract development in mouse. Contrary to expectation, cardiac neural crest and endothelial cells...

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PMID: 18832392
DOI: 10.1242/dev.025437

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An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heartPMID 18832392Read ↗

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