Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2010

Zhao Xianling, Brade Thomas, Cunningham Thomas J, Duester Gregg

Abstract excerpt

Previous studies on retinoic acid receptor (RAR) mutants suggested that retinoic acid (RA) is required for loss of interdigital mesenchyme during digit formation. Here, we report that the RA-generating enzyme retinaldehyde dehydrogenase-2 (Raldh2) is expressed in the interdigital mesenchyme whereas Cyp26b1, controlling RA degradation, is expressed in digits, limiting autopodal RA action to the interdigital zones....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Oxidoreductases
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Fibroblast Growth Factors

Share to Hindlimb

Share to Receptors, Retinoic Acid

Share to SOX9 Transcription Factor

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 20034106
DOI: 10.1002/dvdy.22188
PMCID: PMC2814959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.PMID 20034106Read ↗

HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death.Semantic proximity Read ↗

Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods.Semantic proximity Read ↗

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.Semantic proximity Read ↗

BMP action in skeletogenesis involves attenuation of retinoid signaling.Semantic proximity Read ↗

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures.Semantic proximity Read ↗

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.Semantic proximity Read ↗

Retinoic acid synthesis and hindbrain patterning in the mouse embryo.Semantic proximity Read ↗

Retinoic acid regulates avian lung branching through a molecular networkSemantic proximity Read ↗

Genetic deletion of<i>Cyp26b1</i>negatively impacts limb skeletogenesis by inhibiting chondrogenesisSemantic proximity Read ↗

A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung SpecificationSemantic proximity Read ↗

Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.Semantic proximity Read ↗

Axial skeleton anterior-posterior patterning is regulated through feedback regulation between Meis transcription factors and retinoic acid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.