Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods.

Developmental biology - 1 Apr 1999

Dupé V, Ghyselinck N B, Thomazy V, Nagy L, Davies P J, Chambon P, Mark M

Abstract excerpt

We previously reported that mice lacking the RARgamma gene and one or both alleles of the RARbeta gene (i.e., RARbeta+/-/RARgamma-/- and RARbeta-/-/RARgamma-/- mutants) display a severe and fully penetrant interdigital webbing (soft tissue syndactyly), caused by the persistence of the fetal interdigital mesenchyme (Ghyselinck et al., 1997, Int. J. Dev. Biol. 41, 425-447). In the present study, these compound...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 7
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic and Fetal Development

Share to Forelimb

Share to Metalloendopeptidases

Share to Receptors, Retinoic Acid

Share to Transglutaminases

Share to Tretinoin

Source

Identifiers

PMID: 10075839
DOI: 10.1006/dbio.1998.9176

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods.PMID 10075839Read ↗

Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction.Semantic proximity Read ↗

Rescue of the limb deformity in hammertoe mutant mice by retinoic acid-induced cell death.Semantic proximity Read ↗

Role of the retinoic acid receptor beta (RARbeta) during mouse developmentSemantic proximity Read ↗

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly.Semantic proximity Read ↗

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo.Semantic proximity Read ↗

Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb.Semantic proximity Read ↗

Apoptotic cell death in the mouse limb and its suppression in the hammertoe mutant.Semantic proximity Read ↗

Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.Semantic proximity Read ↗

Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid.Semantic proximity Read ↗

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development.Semantic proximity Read ↗

BMP-2/-4 mediate programmed cell death in chicken limb budsSemantic proximity Read ↗

Syndactyly in a novel Fras1(rdf) mutant results from interruption of signals for interdigital apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.